Neurological Surgery

Surgeons in the Department of Neurosurgery treat adult and pediatric patients with disorders of the nervous system, brain, meninges, skull, and blood supply, the extracranial carotid and vertebral arteries; brain tumors, disorders of the pituitary gland, disorders of the spinal cord, meninges, and vertebral column, including those which may require treatment by spinal fusion or instrumentation; and disorders of the cranial, spinal and peripheral nerves.

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Home > Physicians Directory > Neurological Surgery

Keith M. Rich, MD

Specialty Areas
Neurological Surgery
Neurovascular Disorders
Brain Tumors
Neuro Oncology
Gamma Knife

Areas of Clinical Interest
Neurovascular disorders, stereotactic radiosurgery, stereotactic surgery, cerebrovascular surgery, brain tumors, neuro-oncology, Vagus Nerve Stimulation implantation

Major or Recent Publications/Awards

Honors and Awards
Listed in Best Doctors in America, 2003 - 2009 (Best Doctors, Inc.)
Listed in America's Top Doctors, Castle Connolly Medical Ltd, 2004, - 2008

Book Chapters

Wasserman TH, Simpson JR, Drzymala RE, Rich KM. Stereotactic Irradiation (Radiosurgery). Perez CA, Brady LW, (editors): Principles and Practice of Radiation Oncology (3rd ed.), Chapter 14, Philadelphia: JB Lippincott Co, July 1997

Select Journal Articles

Tabbal S.D., Revilla F.J., Mink, J.W., Schneider-Gibson P, Wernle A.R., de Eurausquin G.A., Perlmutter J.S., Rich K.M., Dowling J.L. Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intra-operative mapping for treatment of Parkinson disease. Neurosurgery, Accepted for publication January 2007.

Jost, S., Chicoine, M., Rich, K.M, Woolsey, T., In vivo imaging in a Murine Model of Glioblastoma. Neurosurgery, Accepted for publication February 2007.

Yuan, L., Siegel, M., Choi, K., Khosla, C., Miller, C.R., Jackson, E.N., Piwnica-Worms, D., Rich, K.M. Transglutaminate 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 10:1038, 2006.

Ushe, M., Mink, J.W., Tabbal, S.D., Hong, M., Schneider, G.P., Rich, K.M., Lyons, K.E., Pahwa, R., Perlmutter, J.S. Postural tremor suppression is dependent on thalamic stimulation frequency. Mov Disord 21(8):1290-1292, 2006.

Hallemeier C.L., Derdeyn C.P., Rich K.M., Grubb T.L., Jr., Chicoine M.R., Moran C.J., Cross D.T., III, Zipfel G.J., Dacey R.G., Jr. Outcome in north american adults with Moyamoya phenomenon. Stroke 37 (6): 1490-1496, 2006.

Rivet, D.J., Goddard, J.K., Rich, K.M., Derdeyn, C.P. Percutaneous transvenous embolization of a dural arteriovenous malformation fistulas through a mastoid emissary vein. Journal of Neurosurgery 105 (4):636-639, 2006.

Drzymala, R.E., Malyapa, R.S., Dowling, J.D., Rich, K.M., Simpson, J.R., Mansur, D.B. Gamma knife radiosurgery for trigeminal neuralgia: The Washington University initial experience. Stereotactic and Functional Neurosurgery 83:148-152, 2005.

Yuan, L., Choi, K., Khosla, C., Zheng, X., Higashikubo, R., Chicoine, M.R., Rich, K.M. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Molecular Cancer Therapeutics 4:1293-302, 2005.

Lytle, R.A., Jiang, Z., Zheng, X., Higashikubo, R., Rich, K.M. Retinamide-induced apoptosis in glioblastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins. Journal of Neuro-Oncology 74:225-32, 2005.

Choi, K., Siegel, M., Piper, J.L., Yuan, L., Cho, E., Strnad, P., Omary, B., Rich, K.M., Khosla, C. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry and Biology 12:469-75, 2005.

Mansur, D.B., Perry, A., Rajaram, V., Michalski, J.M., Park, T.S., Leonard, J.R., Luchtman-Jones, L., Rich, K.M., Grigsby, P.W., Lockett, M.A., Wahab, S.H., Simpson, J.R. Postoperative radiation therapy for grade II and III intracranial ependymoma. International Journal of Radiation Oncology*Biology*Physics 61:387-91, 2005.

Ushe, M., Mink, J.W., Revilla, F.J., Wernle, A., Schneider Gibson P., McGee-Minnich, L., Hong, M., Rich, K.M., Lyons, K.E., Pahwa, R., Perlmutter, J.S. Effect of stimulation frequency on tremor suppression in essential tremor. Movement Disorders 19:1163-8, 2004.

Lytle, R.A., Jiang, Z., Zheng, X., Rich, K.M. BCNU down-regulates anti-apoptotic proteins Bcl-xL and Bcl-2 in association with cell death in oligodendroglioma-derived cells. Journal of Neuro-Oncology 68:233-41, 2004.

Mansur, D.B., Drzymala, R.E., Rich, K.M., Klein, E.E., Simpson, J.R. The efficacy of stereotactic radiosurgery in the management of intracranial ependymoma. Journal of Neuro-Oncology 66:187-190, 2004.

Jiang, Z., Zheng, X., Lytle, R.A., Higashikubo, R., Rich, K.M. Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells. Journal of Neurochemistry 89:168-78, 2004.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. Keith M. Rich

Keith M. Rich, MD